Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 May 26;7(2):E48.
doi: 10.1208/pt070248.

Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: a technical note

Chelakara L Viswanathan  1 , Sushrut K Kulkarni, Dhanashri R Kolwankar
Affiliations
Comparative Study

Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: a technical note

Chelakara L Viswanathan et al. AAPS PharmSciTech. .

Abstract

Spherical agglomeration techniques were developed for improving the flow and compressibility characteristics of microcrystalline mefenamic acid and nabumetone. The process involved agglomerating microcrystals using agglomerating solvents. Temperature and speed of agitation were optimized to obtain spherical agglomerates in a desired range, which was found to be essential to enhance compressibility. Incorporation of polymer HPMC during agglomeration significantly enhanced the dissolution rate of mefenamic acid while incorporation of solubilizing agent lecithin improved the solubility of nabumetone. Thus, spherical agglomeration is an important technique for improving direct compressibility of pharmaceutical powders and is especially useful when the drug dosage is high.

PubMed Disclaimer

References

    1. Atkinson RM, Belford C, Tomich EG. Effect of particle size on blood Griseofulvin levels in man. Nature. 1962;193:588–589. doi: 10.1038/193588a0. - DOI - PubMed
    1. Prescott LF, Steel RF, Ferrier WR. The effect of particle size on the absorption of Phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system. Clin Pharmacol Ther. 1970;11:496–504. - PubMed
    1. Kawashima Y, Okumara M, Takenaka H. A novel agglomeration technique to transform a microcrystalline drug into an agglomerated form during crystallization. Science. 1982;216:1127–1128. doi: 10.1126/science.216.4550.1127. - DOI - PubMed
    1. Kawashima Y, Okumara M, Takenaka H, Kojwa A. Direct preparation of spherically agglomerated salicylic acid crystals during crystallization. J Pharm Sci. 1984;73:1535–1538. doi: 10.1002/jps.2600731110. - DOI - PubMed
    1. Gordon MS, Chowhan LT. Manipulation of naproxen particle morphology via the spherical crystallization technique to achieve a directly compressible raw material. Drug Dev Ind Pharm. 1990;16:1279–1290. doi: 10.3109/03639049009115961. - DOI

Publication types

MeSH terms

LinkOut - more resources