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Randomized Controlled Trial
. 2006 Sep;62(3):372-6.
doi: 10.1111/j.1365-2125.2006.02689.x. Epub 2006 Jun 23.

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Mikiko Shimizu  1 , Tsukasa Uno, Kazunobu Sugawara, Tomonori Tateishi
Affiliations
Randomized Controlled Trial

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Mikiko Shimizu et al. Br J Clin Pharmacol. 2006 Sep.

Abstract

Aims: We determined whether or not the extent of drug interaction of fexofenadine by itraconazole is time-dependent.

Methods: In a randomized two-phase crossover study, itraconazole was administered orally for 6 days, and, on days 1, 3 and 6, fexofenadine was administered simultaneously. On another occasion, fexofenadine was administered alone.

Results: Itraconazole increased fexofenadine AUC(0, infinity), and the % change for difference was 178% (95% CI 1235, 3379), 205% (95% CI 1539, 3319) and 169% (95% CI 1128, 2987) on days 1, 3 and 6 of the 6 day treatment, respectively.

Conclusions: The extent of drug interaction by itraconazole was not time-dependent.

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