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Case Reports
. 2006 Sep;102(3):421-4.
doi: 10.1016/j.ygyno.2006.04.025. Epub 2006 Jun 23.

Activity of trabectedin (ET-743, Yondelis) in metastatic uterine leiomyosarcoma

Devansu Tewari  1 , Bahman Saffari, Carol Cowan, Anita C Wallick, M Zach Koontz, Bradley J Monk
Affiliations
Case Reports

Activity of trabectedin (ET-743, Yondelis) in metastatic uterine leiomyosarcoma

Devansu Tewari et al. Gynecol Oncol. 2006 Sep.

Abstract

Background: The ongoing search for more effective agents in the treatment of uterine leiomyosarcomas is warranted because of the poor prognosis related to these tumors.

Case: A case of advanced, recurrent and refractory uterine leiomyosarcoma is presented that responded to trabectedin (ET-743) 1.2 mg/m2 intravenously over 24 h every 3 weeks after failing four prior regimens. A durable objective response lasting at least 8 months was documented.

Conclusion: Trabectedin (ET-743) has activity in uterine leiomyosarcoma and warrants further investigation.

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