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Review
. 2006 Sep;71(2-3):276-81.
doi: 10.1016/j.antiviral.2006.04.017. Epub 2006 May 23.

L-nucleoside enantiomers as antivirals drugs: a mini-review

Christophe Mathé  1 , Gilles Gosselin
Affiliations
Review

L-nucleoside enantiomers as antivirals drugs: a mini-review

Christophe Mathé et al. Antiviral Res. 2006 Sep.

Abstract

The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents.

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