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. 2006 Jul:86 Suppl 1:S9-S11.
doi: 10.1016/j.fertnstert.2006.03.015.

Ovarian enzyme activities in women with polycystic ovary syndrome

Denis A Magoffin  1
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Free article

Ovarian enzyme activities in women with polycystic ovary syndrome

Denis A Magoffin. Fertil Steril. 2006 Jul.
Free article

Abstract

Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.

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