Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Jul;50(7):2522-4.
doi: 10.1128/AAC.00148-06.

Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy

Morgan Hakki  1 , Janet F Staab, Kieren A Marr
Affiliations
Case Reports

Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy

Morgan Hakki et al. Antimicrob Agents Chemother. 2006 Jul.

Abstract

Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Fundoscopic appearance of right eye lesion (indicated by the arrows) at presentation (A) and after 2 weeks of liposomal amphotericin B followed by 4 weeks of voriconazole (B).
FIG. 2.
FIG. 2.
HinfI restriction endonuclease digestion patterns of C. krusei isolates. Lane 1, unrelated C. krusei isolate; lane 2, patient's blood isolate; lane 3, patient's throat isolate. A DNA molecular size ladder (kb) is shown to the left of the gel.
See this image and copyright information in PMC

References

    1. Anonymous. 2003. Cancidas (package insert). Merck, Rahway, N.J.
    1. Canton, E., J. Peman, M. Gobernado, E. Alvarez, F. Baquero, R. Cisterna, J. Gil, E. Martin-Mazuelos, C. Rubio, A. Sanchez-Sousa, and C. Serrano. 2005. Sensititre YeastOne caspofungin susceptibility testing of Candida clinical isolates: correlation with results of NCCLS M27-A2 multicenter study. Antimicrob. Agents Chemother. 49:1604-1607. - PMC - PubMed
    1. Cowen, L. E., and S. Lindquist. 2005. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309:2185-2189. - PubMed
    1. Deresinski, S. C., and D. A. Stevens 2003. Caspofungin. Clin. Infect. Dis. 36:1445-1457. - PubMed
    1. Douglas, C. M., J. A. D'Ippolito, G. J. Shei, M. Meinz, J. Onishi, J. A. Marrinan, W. Li, G. K. Abruzzo, A. Flattery, K. Bartizal, A. Mitchell, and M. B. Kurtz. 1997. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-β-d-glucan synthase inhibitors. Antimicrob. Agents Chemother. 41:2471-2479. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources