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. 2006 Jul;50(7):2525-9.
doi: 10.1128/AAC.01489-05.

Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures

Ilya Lebeau  1 , Graciela Andrei, Fabiana Dal Pozzo, James R Beadle, Karl Y Hostetler, Erik De Clercq, Joost van den Oord, Robert Snoeck
Affiliations

Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures

Ilya Lebeau et al. Antimicrob Agents Chemother. 2006 Jul.

Abstract

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.

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Figures

FIG. 1.
FIG. 1.
Effects of alkoxyalkyl esters of CDV, cCDV, and HPMPA on extracellular VV production in HEL fibroblast monolayers (A) and PHK monolayers (B).
FIG. 2.
FIG. 2.
Activities of CDV, ODBG-CDV, and OLE-CDV against VV in organotypic epithelial raft cultures of PHK cells.
FIG. 3.
FIG. 3.
Activities of HPMPA, ODE-HPMPA, and HDP-HPMPA against VV in organotypic epithelial raft cultures of PHK cells.
See this image and copyright information in PMC

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