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. 2006 Jul;50(7):2530-2.
doi: 10.1128/AAC.00238-06.

Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x

Todd A Davies  1 , Wenchi Shang, Karen Bush
Affiliations

Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x

Todd A Davies et al. Antimicrob Agents Chemother. 2006 Jul.

Abstract

The activities of ceftobiprole and other beta-lactams were examined with 30 Streptococcus pneumoniae isolates containing multiple pbp1a, pbp2b, and pbp2x mutations. The highest ceftobiprole MIC was 1 microg/ml, while the comparator MICs were 16 to 64 microg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 microg/ml (ceftobiprole) and 4 microg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.

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Figures

FIG. 1.
FIG. 1.
Binding of ceftobiprole and ceftriaxone to PBPs 2x, 2a, and 2b from S. pneumoniae isolate 8819 (penicillin resistant, ceftriaxone resistant).
See this image and copyright information in PMC

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