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. 2006 Jul;50(7):2560-2.
doi: 10.1128/AAC.00264-06.

Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible

Nadya Andini  1 , Kevin A Nash
Affiliations

Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible

Nadya Andini et al. Antimicrob Agents Chemother. 2006 Jul.

Abstract

Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm(37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.

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Figures

FIG. 1.
FIG. 1.
A. The level of erm(37) mRNA in M. tuberculosis 24 h after the addition of clarithromycin (CLR) (1, 2, 4, 8, 16, and 32 μg/ml). Relative expression represents mRNA levels from each experimental condition compared to those of organisms incubated in medium alone (0 μg/ml). B. The change in erm(37) mRNA levels in M. tuberculosis following addition of clarithromycin (2 μg/ml) relative to the mRNA levels at time zero. Inset—change in erm(37) mRNA levels (relative to time zero) of M. microti (micr) and M. tuberculosis (tb) incubated for 18 h with clarithromycin at 0.1 and 2 μg/ml, respectively. Each experimental condition was tested in triplicate.
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