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. 2006 Jul;29(7):1535-7.
doi: 10.2337/dc05-1367.

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance

Betty A Maddux  1 , Adelene Chan, Elena A De Filippis, Lawrence J Mandarino, Ira D Goldfine
Affiliations

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance

Betty A Maddux et al. Diabetes Care. 2006 Jul.

Erratum in

  • Diabetes Care. 2006 Nov;29(11):2571. De Filippis, Elena A [added]

Abstract

Objective: IGF-binding protein (IGFBP)-1 is negatively regulated by insulin. We determined whether the measurement of IGFBP-1 in serum is a useful marker of insulin resistance.

Research design and methods: Twenty-three subjects underwent a euglycemic insulin clamp. Glucose disposal rates (M) were then correlated with measurements of IGFBP-1, fasting insulin levels, homeostasis model assessment (HOMA), and BMI.

Results: IGFBP-1 levels more strongly correlated with M (R = 0.73) than the other parameters such as BMI or HOMA. The level of this protein decreased in individuals who became more insulin sensitive by exercise training.

Conclusions: These studies show a strong correlation between insulin sensitivity and the serum levels of IGFBP-1. These studies suggest, therefore, that measurement of this protein may be valuable in identifying those individuals with insulin resistance and those individuals who respond to interventional strategies.

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