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. 2006 Jul;60(1):145-7.
doi: 10.1002/ana.20889.

Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study

Hilary A Archer  1 , Paul Edison, David J Brooks, Jo Barnes, Chris Frost, Tom Yeatman, Nick C Fox, Martin N Rossor
Affiliations

Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study

Hilary A Archer et al. Ann Neurol. 2006 Jul.

Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

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