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. 2006 Jul 5;128(26):8384-5.
doi: 10.1021/ja061717a.

Oxide hemostatic activity

Todd A Ostomel  1 , Qihui Shi, Galen D Stucky
Affiliations

Oxide hemostatic activity

Todd A Ostomel et al. J Am Chem Soc. .

Abstract

The tunable in vitro blood clotting activity of high-surface-area hemostatic bioactive glass is evaluated by Thromboelastograph, a clinical instrument for quantifying changes in blood during coagulation. The hemostatic trends associated with hemostatic bioactive glass and a new preparation of spherical hemostatic bioactive glass, along with similar Si- and Ca-containing oxides, are described and related to Si:Ca ratios, Ca2+ availability and coordination environment, porosity, DeltaHHydration, and surface area. Hemostatic bioactive glass is a new material with an excellent efficacy for inducing hemostasis and is chemically distinct from the traditional bioglass employed for bone growth.

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