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Comparative Study
. 1991 Sep 16;179(2):847-51.
doi: 10.1016/0006-291x(91)91895-j.

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease

H J Schramm  1 , H Nakashima, W Schramm, H Wakayama, N Yamamoto
Affiliations
Comparative Study

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease

H J Schramm et al. Biochem Biophys Res Commun. .

Abstract

Two octapeptides derived from the sequence of the N- and C-termini of HIV-1 protease were tested for their ability to inhibit HIV-1 reproduction. Weak inhibitory activity was found with each of the two peptides. It is assumed that HIV-1 protease is the target of the inhibitory action. In spite of the moderate inhibitory activity the results are encouraging since they may be improved by various means.

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