Review
doi: 10.1196/annals.1354.026.
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints
Affiliations
- PMID: 16803988
- DOI: 10.1196/annals.1354.026
Item in Clipboard
Review
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints
Ann N Y Acad Sci.
2006 May.
Abstract
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Similar articles
-
Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.Biochem J. 2004 Jun 15;380(Pt 3):605-10. doi: 10.1042/BJ20040337. Biochem J. 2004. PMID: 15109303 Free PMC article.
-
CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway.Int J Oncol. 2008 Mar;32(3):663-71. Int J Oncol. 2008. PMID: 18292944
-
CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.Ann N Y Acad Sci. 2007 Apr;1100:312-5. doi: 10.1196/annals.1395.033. Ann N Y Acad Sci. 2007. PMID: 17460193
-
CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.Mech Ageing Dev. 2017 Sep;166:64-68. doi: 10.1016/j.mad.2017.07.008. Epub 2017 Jul 25. Mech Ageing Dev. 2017. PMID: 28754531 Review.
-
p53-Dependent and -independent functions of the Arf tumor suppressor.Cold Spring Harb Symp Quant Biol. 2005;70:129-37. doi: 10.1101/sqb.2005.70.004. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869746 Review.
Cited by
-
Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.PLoS One. 2014 May 1;9(5):e95561. doi: 10.1371/journal.pone.0095561. eCollection 2014. PLoS One. 2014. PMID: 24788674 Free PMC article.
-
Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.Cancer Lett. 2009 Nov 1;284(2):149-56. doi: 10.1016/j.canlet.2009.04.017. Epub 2009 May 19. Cancer Lett. 2009. PMID: 19457610 Free PMC article.
-
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation.Cells. 2022 Mar 9;11(6):935. doi: 10.3390/cells11060935. Cells. 2022. PMID: 35326386 Free PMC article.
-
NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0/G1 phase arrest and upregulation of CDKN2AIP expression.Int J Biol Sci. 2024 Oct 28;20(15):5850-5867. doi: 10.7150/ijbs.95174. eCollection 2024. Int J Biol Sci. 2024. PMID: 39664575 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
