doi: 10.1038/ng0706-731.
Statistical false positive or true disease pathway?
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- PMID: 16804532
- DOI: 10.1038/ng0706-731
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Statistical false positive or true disease pathway?
Nat Genet.
2006 Jul.
Abstract
Three very recent reports provide convincing statistical evidence (P < 10(-8)), at a genome-wide level, of the association of common polymorphisms with three different common diseases: systemic lupus erythematosus (IRF5), prostate cancer and type 1 diabetes (IFIH1 region). This adds to the trickle--soon to be a flood--of disease association results that are highly unlikely to be false positives. There are other convincing examples in the last 12 months: age-related macular degeneration (CFH), type 1 diabetes (IL2RA, also known as CD25) and type 2 diabetes (TCF7L2). Given 20 years of a literature full of irreproducible results, what has changed?
Comment in
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On the parsing of statistical information in family-based association testing.Nat Genet. 2007 Mar;39(3):281-2. doi: 10.1038/ng0307-281. Nat Genet. 2007. PMID: 17325672 No abstract available.
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