Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jun 29:4:26.
doi: 10.1186/1476-7120-4-26.

Is there a role of statins in the prevention of aortic biological prostheses degeneration

Francesco Antonini-Canterin  1 , Alfredo Zuppiroli, Ferdinando Baldessin, Bogdan A Popescu, Gian Luigi Nicolosi
Affiliations
Review

Is there a role of statins in the prevention of aortic biological prostheses degeneration

Francesco Antonini-Canterin et al. Cardiovasc Ultrasound. .

Abstract

It has been recently observed that statins might slow the progression of aortic stenosis or sclerosis. Preliminary reports suggested a similar positive effect in reducing the degeneration of aortic valve bioprostheses even though this hypothesis should be further proven and supported by new data. In this review the present evidences of the possible effects of statins in this field are discussed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Peak Prosthetic Velocity and Prosthetic Indexed Effective Orifice Area. Comparison of Annual Rate of increase in Peak Prosthetic Velocity (m/s/yr) and annual rate of change in Prosthetic Indexed Effective Orifice Area (EOA) (cm2/m2/yr) in patients with statins therapy and those without.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bloomfield P, Wheatley DJ, Prescott RJ, Miller HC. Twelve-year comparison of a Bjork-Shiley mechanical heart valve with porcine bioprosthesis. N Engl J Med. 1991;324:573–579. - PubMed
    1. Hammermeister K, Sethi GK, Henderson WG, Grover FL, Oprian C, Rahimtoola S. Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs Randomized Trial. J Am Coll Cardiol. 2000;36:1152–1158. doi: 10.1016/S0735-1097(00)00834-2. - DOI - PubMed
    1. UK Heart Valve Registry. London: Imperial College School of Medicine, Hammersmith Hospital; 1999. The United Kingdom Heart Valve Registry Report 1997.
    1. Treasure T. Rethink on biological aortic valves for the elderly. Lancet. 1999;354:964–965. doi: 10.1016/S0140-6736(99)00198-1. - DOI - PubMed
    1. Aronow WS, Ahn C, Kronzon I, Goldman ME. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol. 2001;88:693–695. doi: 10.1016/S0002-9149(01)01821-5. - DOI - PubMed

MeSH terms

Substances