doi: 10.1016/j.bmcl.2006.06.048.
Epub 2006 Jun 27.
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase
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- PMID: 16806925
- DOI: 10.1016/j.bmcl.2006.06.048
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Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase
Bioorg Med Chem Lett.
.
Abstract
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.
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