Closing the link in short-loop prolactin feedback
- PMID: 16806965
- DOI: 10.1016/j.tem.2006.06.005
Closing the link in short-loop prolactin feedback
Abstract
Short-loop negative feedback actions of prolactin in hypothalamus have been recognized for some time. Two recent papers demonstrate the multiple sites of this feedback action and the signaling mechanisms involved.
Comment on
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Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons.Endocrinology. 2006 Mar;147(3):1195-202. doi: 10.1210/en.2005-0905. Epub 2005 Dec 15. Endocrinology. 2006. PMID: 16357045
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Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons.Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1216-25. doi: 10.1152/ajpregu.00730.2005. Epub 2006 Jan 12. Am J Physiol Regul Integr Comp Physiol. 2006. PMID: 16410399
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