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. 1975 May;54(1):1-10.
doi: 10.1111/j.1432-1033.1975.tb04106.x.

Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells

J Content, B Lebleu, U Nudel, A Zilberstein, H Berissi, M Revel
Free article

Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells

J Content et al. Eur J Biochem. 1975 May.
Free article

Abstract

Synthesis of polypeptide chains coded by exogenous messenger RNAs is inhibited in cell-free extracts from interferon-treated mouse L cells, due to a "deficiency" in some specific tRNA species. A detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. After a few minutes, however, initiation of new polypeptide chains is also blocked. Messenger RNA still binds to ribosomes but initiator Met-tRNA(FMET) binding is inhibited. The block in initiation appears to be secondary to the block in elongation.

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