doi: 10.1111/j.1432-1033.1975.tb04106.x.
Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells
- PMID: 168074
- DOI: 10.1111/j.1432-1033.1975.tb04106.x
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Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells
Eur J Biochem.
1975 May.
Free article
Abstract
Synthesis of polypeptide chains coded by exogenous messenger RNAs is inhibited in cell-free extracts from interferon-treated mouse L cells, due to a "deficiency" in some specific tRNA species. A detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. After a few minutes, however, initiation of new polypeptide chains is also blocked. Messenger RNA still binds to ribosomes but initiator Met-tRNA(FMET) binding is inhibited. The block in initiation appears to be secondary to the block in elongation.
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