Comparative Study
doi: 10.1016/0014-5793(91)81248-7.
Heterogeneity in human soluble guanylate cyclase due to alternative splicing
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- PMID: 1680753
- DOI: 10.1016/0014-5793(91)81248-7
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Comparative Study
Heterogeneity in human soluble guanylate cyclase due to alternative splicing
FEBS Lett.
.
Free article
Abstract
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.
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