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Comparative Study
. 1991 Sep 23;290(1-2):157-8.
doi: 10.1016/0014-5793(91)81248-7.

Heterogeneity in human soluble guanylate cyclase due to alternative splicing

V Chhajlani  1 , P A Frändberg, J Ahlner, K L Axelsson, J E Wikberg
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Free article
Comparative Study

Heterogeneity in human soluble guanylate cyclase due to alternative splicing

V Chhajlani et al. FEBS Lett. .
Free article

Abstract

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.

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