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Review
. 2006;8(2):E409-12.
doi: 10.1007/BF02854913.

2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook

Anita Hermann  1 , Martin Kaczocha, Dale G Deutsch
Affiliations
Review

2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook

Anita Hermann et al. AAPS J. 2006.

Abstract

Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake of 2-AG is discussed in light of the recent advances that have been made for anandamide transport, where the mechanism appears to be rate-limited diffusion through the membrane. Endocannabinoids may be a distinct class of agonists since they are hydrophobic and neutral, exhibiting similar biophysical properties to some anesthetics that freely diffuse through the membrane.

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References

    1. Sugiura T, Kondo S, Sukagawa A, et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun. 1995;215:89–97. doi: 10.1006/bbrc.1995.2437. - DOI - PubMed
    1. Mechoulam R, Ben-Shabat S, Hanus L, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol. 1995;50:83–90. doi: 10.1016/0006-2952(95)00109-D. - DOI - PubMed
    1. Piomelli D. The challenge of brain lipidomics. Prostaglandins Other Lipid Mediat. 2005;77:23–34. doi: 10.1016/j.prostaglandins.2004.09.006. - DOI - PubMed
    1. Jonsson KO, Holt S, Fowler CJ. The endocannabinoid system: current pharmacological research and therapeutic possibilities. Basic Clin Pharmacol Toxicol. 2006;98:124–134. doi: 10.1111/j.1742-7843.2006.pto_376.x. - DOI - PubMed
    1. Di Marzo V. A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists. Trends Pharmacol Sci. 2006;27:134–140. doi: 10.1016/j.tips.2006.01.010. - DOI - PubMed

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