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Review
. 2006 Sep 1;575(Pt 2):317-8.
doi: 10.1113/jphysiol.2006.114629. Epub 2006 Jun 29.

Malevolent lurkers no more: NMDA receptors come of age

Chris J McBain  1 , Stephen F Traynelis
Affiliations
Review

Malevolent lurkers no more: NMDA receptors come of age

Chris J McBain et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1. Dual-component excitatory postsynaptic currents and bursts
A, averages of five successive currents recorded in the presence of 1 mm Mg2+ and 50 μm picrotoxin are shown at three membrane potentials in control solution (left), 20 μm APV (centre), and the difference between them (APV-sensitive component; right). B, the peak amplitudes of the APV-resistant (•) and the APV-sensitive (□) components are plotted against voltage-clamped membrane potential. Reversal potentials for the two components were −5 and 0 mV, respectively. C, the APV-resistant and APV-sensitive EPSC components recorded at −23 mV are superimposed to aid comparison of their time courses. Reproduced with permission from Collingridge et al. (1988). D and E, reduction in amplitude of the paroxysmal depolarizing shift waveform by blockade of NMDA receptors. Bursts evoked by 0.1 Hz stimulation of Schaffer-commissural path (Di) or occurring spontaneously (Ei) were recorded in the presence of 100 μm picrotoxin. After pressure ejection of a droplet of d-APV (85 μm) onto the slice surface, the amplitude of the depolarization underlying both types of burst was decreased (Dii and Eii). Resting membrane potentials were −61 mV (D) and −63 mV (E) and input resistances were 40 MΩ (D) and 48 MΩ (E). Reproduced with permission form Dingledine et al. (1986).
See this image and copyright information in PMC

Comment on

References

    1. Bekkers JM, Stevens CF. Nature. 1989;341:230–233. - PubMed
    1. Collingridge GL, Herron CE, Lester RAJ. J Physiol. 1988;399:283–300. - PMC - PubMed
    1. Dale N, Roberts A. J Physiol. 1985;363:35–59. - PMC - PubMed
    1. Davies J, Francis AA, Jones AW, Watkins JC. Neurosci Lett. 1981;21:77–81. - PubMed
    1. Dingledine R. Tr Neurosci. 1986;9:47–49.