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. 2006 Aug;37(8):2162-4.
doi: 10.1161/01.STR.0000231648.74198.f7. Epub 2006 Jun 29.

An integrated automated analysis method for quantifying vessel stenosis and plaque burden from carotid MRI images: combined postprocessing of MRA and vessel wall MR

Isabel M Adame  1 , Patrick J H de Koning, Boudewijn P F Lelieveldt, Bruce A Wasserman, Johan H C Reiber, Rob J van der Geest
Affiliations

An integrated automated analysis method for quantifying vessel stenosis and plaque burden from carotid MRI images: combined postprocessing of MRA and vessel wall MR

Isabel M Adame et al. Stroke. 2006 Aug.

Abstract

Background and purpose: We report the evaluation of a semiautomated method for in vivo assessment of the severity of carotid atherosclerosis with minimal user interaction that combines 3-dimensional contrast-enhanced magnetic resonance angiography (CE-MRA) and vessel wall magnetic resonance imaging (MRI).

Methods: Lumen and outer-wall contours were automatically detected, and stenosis and plaque burden were estimated. The method was tested on 22 subjects (352 postcontrast, T1-weighted cross sections and 3-dimensional CE-MRA).

Results: We observed good correlation with expert contours: lumen and outer-wall area (r=0.96) and the degree of stenosis (r=0.97).

Conclusions: The fusion of MRA and MRI reduces user interaction and improves contour detection, providing reproducible parameters to assess the severity of atherosclerosis.

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