Comparative Study
doi: 10.1007/BF00429834.
The excretion of proinsulin and insulin in urine
- PMID: 168106
- DOI: 10.1007/BF00429834
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Comparative Study
The excretion of proinsulin and insulin in urine
Diabetologia.
1975 Apr.
Abstract
Proinsulin-like components (PLC) and insulin have been measured in 24 hr urine samples from 8 healthy subjects. The mean excretion of PLC was 45.8 ng and that of insulin 314 ng; the PLC: insulin ratio was 0.14. Urinary PLC was increased 3.5 fold in a patient with a pancreatic islet cell tumor and the PLC: insulin ratio was 0.35. The urinary PLC: insulin ratio is lower than that of serum, presumably because of the relatively lower urinary clearance of the larger molecular weight PLC.
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