Resistance of Salmonella typhi to chloramphenicol: Part II The mechanism of resistance
- PMID: 16810989
- PMCID: PMC480456
- DOI: 10.1136/jcp.15.6.548
Resistance of Salmonella typhi to chloramphenicol: Part II The mechanism of resistance
Abstract
A study of the action of the culture filtrates of 10 strains of S. typhi resistant to chloramphenicol showed that two of the strains produced an extracellular substance which enabled a strain of S. typhi sensitive to chloramphenicol to grow in a mixture of the filtrate and the antibiotic. A study of the properties of this substance suggested that it was an enzyme.
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