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Multicenter Study
. 2006 Jun 30;7(1):94.
doi: 10.1186/1465-9921-7-94.

Reference values for exhaled nitric oxide (reveno) study

Mario Olivieri  1 , Giorgio Talamini, Massimo Corradi, Luigi Perbellini, Antonio Mutti, Claudio Tantucci, Mario Malerba
Affiliations
Multicenter Study

Reference values for exhaled nitric oxide (reveno) study

Mario Olivieri et al. Respir Res. .

Abstract

Background: Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults.

Objective: The aim of this study was to establish adult FENO reference values according to the international guidelines.

Methods: FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently.

Results: The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women.

Conclusion: We propose reference FENO values for healthy adult men and women that could be used for clinical and research purposes.

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Figures

Figure 1
Figure 1
Fractional exhaled nitric oxide (FENO) levels in men and women at three expiratory flows. Mean values and 95% confidence intervals.
See this image and copyright information in PMC

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