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. 2006 Sep 15;16(18):4879-83.
doi: 10.1016/j.bmcl.2006.06.066. Epub 2006 Jun 30.

Discovery of a novel series of inhibitors of human cytomegalovirus primase

T D Cushing  1 , J Adrian, X Chen, H DiMaio, B Doughan, J Flygare, L Liang, V Mayorga, S Miao, H Mellon, M G Peterson, J P Powers, F Spector, C Stein, M Wright, D Xu, Q Ye, J Jaen
Affiliations

Discovery of a novel series of inhibitors of human cytomegalovirus primase

T D Cushing et al. Bioorg Med Chem Lett. .

Abstract

Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on results from radiolabeling and SAR studies. Two promising analogs are described that rival ganciclovir and cidofovir in antiviral potency and possess improved cytotoxicity profiles.

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