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Case Reports
. 2006 Jul;13(6):683-7.
doi: 10.1016/j.jocn.2005.09.008. Epub 2006 Jun 30.

Rituximab therapy in chronic inflammatory demyelinating polyradiculoneuropathy with anti-SGPG IgM antibody

Takahisa Gono  1 , Masayuki Matsuda, Yasuhiro Shimojima, Wataru Ishii, Kanji Yamamoto, Hiroshi Morita, Takao Hashimoto, Keiichiro Susuki, Nobuhiro Yuki, Shu-ichi Ikeda
Affiliations
Case Reports

Rituximab therapy in chronic inflammatory demyelinating polyradiculoneuropathy with anti-SGPG IgM antibody

Takahisa Gono et al. J Clin Neurosci. 2006 Jul.

Abstract

We report a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who showed high titers of anti-sulfated glucuronyl paragloboside (SGPG) IgM antibody without M-protein in serum. The patient was resistant to corticosteroids and immunosuppressants, but after administration of rituximab, clinical symptoms improved and the patient remained in a stable state for approximately 10 months. Rituximab may be a potent therapeutic option for refractory cases of CIDP irrespective of detectable M-protein in either serum or urine.

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