Review
doi: 10.1016/j.cmet.2006.06.004.
p53 aerobics: the major tumor suppressor fuels your workout
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- PMID: 16814724
- DOI: 10.1016/j.cmet.2006.06.004
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Review
p53 aerobics: the major tumor suppressor fuels your workout
Cell Metab.
2006 Jul.
Free article
Abstract
In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.
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