Review
doi: 10.1016/j.neuron.2006.06.019.
Neurotrophins and dementia--keeping in touch
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- PMID: 16815323
- DOI: 10.1016/j.neuron.2006.06.019
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Review
Neurotrophins and dementia--keeping in touch
Neuron.
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Abstract
Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain. Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome.
Comment on
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In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model.Neuron. 2006 Jul 6;51(1):21-8. doi: 10.1016/j.neuron.2006.06.009. Neuron. 2006. PMID: 16815329
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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.Neuron. 2006 Jul 6;51(1):29-42. doi: 10.1016/j.neuron.2006.05.022. Neuron. 2006. PMID: 16815330
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