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Review
. 2006 Aug;9(4):430-6.
doi: 10.1016/j.mib.2006.06.008. Epub 2006 Jul 3.

Viruses and sumoylation: recent highlights

Roberto Boggio  1 , Susanna Chiocca
Affiliations
Review

Viruses and sumoylation: recent highlights

Roberto Boggio et al. Curr Opin Microbiol. 2006 Aug.

Abstract

Since its discovery in 1997, SUMO (small ubiquitin-like modifier) has been implicated in a range of activities, indicating that this protein is as important in the cell as ubiquitin is. Although it can function throughout the cell, it appears to be involved more in nuclear functions. The growing list of substrates that are covalently modified by SUMO includes many viral proteins; SUMO appears to facilitate viral infection of cells, making it a possible target for antiviral therapies. It therefore is important to understand how viruses manipulate the cellular sumoylation system and how sumoylation affects viral functions.

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Figures

Figure 1
Figure 1
The viral proteins discussed in this review and their interaction with the SUMO pathway. The upper panel shows how viral proteins could counteract the host's sumoylation, either by preventing de novo sumoylation (HCMV-IE1), by enhancing de-sumoylation (HSV-ICP0) or by inhibiting the sumoylation enzymatic cascade (Gam1; middle panel). Some viral proteins could exploit the host's sumoylation because they need to be SUMO-modified in order to exert their functions (lower panel). Abbreviations: S, SUMO; E1, SUMO-activating enzyme (SAE1/SAE2); E2, SUMO-conjugating enzyme (UBC9); E3, SUMO-ligases.
See this image and copyright information in PMC

References

    1. Melchior F. SUMO—nonclassical ubiquitin. Annu Rev Cell Dev Biol. 2000;16:591–626. - PubMed
    1. Gill G. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev. 2004;18:2046–2059. - PubMed
    1. Rosas-Acosta G.W.V. Viruses and sumoylation. In: Wilson V.G., editor. Sumoylation: Molecular Biology and BIochemistry. Horizon Bioscience; 2004. pp. 331–377.

    2. An excellent review that focuses on all viruses known to interact with the host sumoylation system.

    1. Hay R.T. SUMO: a history of modification. Mol Cell. 2005;18:1–12. - PubMed

    2. This is a very well written recent and comprehensive review on SUMO.

    1. Boggio R., Colombo R., Hay R.T., Draetta G.F., Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004;16:549–561. - PubMed

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