The vertebral endplate: disc degeneration, disc regeneration
- PMID: 16816945
- PMCID: PMC2335377
- DOI: 10.1007/s00586-006-0170-4
The vertebral endplate: disc degeneration, disc regeneration
Abstract
The vertebral endplates are critical for maintaining disc function yet like other components of the disc are vulnerable to degeneration. This paper provides an overview of the development and normal function of the endplates as well as an impression of what happens when they undergo progressive degeneration. Recent research suggests that the degenerative process can be retarded or reversed.
Similar articles
-
World Forum for Spine Research: the intervertebral disc: first Japanese meeting, Kyoto, Japan, 23-26 January 2008.Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):419-20. doi: 10.1007/s00586-008-0742-6. Epub 2008 Nov 13. Eur Spine J. 2008. PMID: 19005705 Free PMC article. No abstract available.
-
Experimental disc degeneration due to endplate injury.J Spinal Disord Tech. 2004 Feb;17(1):64-71. doi: 10.1097/00024720-200402000-00012. J Spinal Disord Tech. 2004. PMID: 14734978
-
The pathophysiology of the intervertebral disc.Joint Bone Spine. 2001 Dec;68(6):537-42. doi: 10.1016/s1297-319x(01)00332-3. Joint Bone Spine. 2001. PMID: 11808995 Review.
-
Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc.Eur Spine J. 2006 Aug;15 Suppl 3(Suppl 3):S414-21. doi: 10.1007/s00586-006-0172-2. Epub 2006 Jul 26. Eur Spine J. 2006. PMID: 16868785 Free PMC article. Review.
-
New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain.J Orthop Res. 2016 Aug;34(8):1287-8. doi: 10.1002/jor.23375. J Orthop Res. 2016. PMID: 27571441 Free PMC article. No abstract available.
Cited by
-
Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.PLoS One. 2015 Feb 10;10(2):e0116625. doi: 10.1371/journal.pone.0116625. eCollection 2015. PLoS One. 2015. PMID: 25668621 Free PMC article.
-
The Impact of Vertebral End Plate Lesions on the Radiological Outcome in Oblique Lateral Interbody Fusion.Global Spine J. 2021 Oct;11(8):1176-1182. doi: 10.1177/2192568220941447. Epub 2020 Aug 3. Global Spine J. 2021. PMID: 32744116 Free PMC article.
-
Foxa1 and Foxa2 are required for formation of the intervertebral discs.PLoS One. 2013;8(1):e55528. doi: 10.1371/journal.pone.0055528. Epub 2013 Jan 31. PLoS One. 2013. PMID: 23383217 Free PMC article.
-
Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.J Neuroinflammation. 2025 Jan 22;22(1):13. doi: 10.1186/s12974-025-03335-4. J Neuroinflammation. 2025. PMID: 39844302 Free PMC article.
-
Vertebral subchondral bone.Osteoporos Int. 2012 Dec;23 Suppl 8:S857-60. doi: 10.1007/s00198-012-2164-x. Epub 2012 Nov 22. Osteoporos Int. 2012. PMID: 23179569 Review.
References
-
- Aigner T, Gresk-Otter KR, Fairbank JC et al (1998) Variation with age in the pattern of type X collagen expression in normal and scoliotic human intervertebral discs. CalcifTissue Int 63:263–268 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources