Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jul 12;128(27):8738-9.
doi: 10.1021/ja062666k.

A genetically encoded fluorescent amino acid

Jiangyun Wang  1 , Jianming Xie, Peter G Schultz
Affiliations

A genetically encoded fluorescent amino acid

Jiangyun Wang et al. J Am Chem Soc. .

Abstract

The fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine 1 has been genetically encoded in E. coli in response to the amber TAG codon. Because of its high fluorescence quantum yield, relatively large Stoke's shift, and sensitivity to both pH and polarity, this amino acid should provide a useful probe of protein localization and trafficking, protein conformation changes, and protein-protein interactions.

PubMed Disclaimer

Publication types

MeSH terms