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. 1991 Dec;59(12):4724-8.
doi: 10.1128/iai.59.12.4724-4728.1991.

Inability to express fimbriae results in impaired ability of Haemophilus influenzae b to colonize the nasopharynx

A Weber  1 , K Harris, S Lohrke, L Forney, A L Smith
Affiliations

Inability to express fimbriae results in impaired ability of Haemophilus influenzae b to colonize the nasopharynx

A Weber et al. Infect Immun. 1991 Dec.

Abstract

We cloned into the structural fimbrial subunit gene from a fimbriated Haemophilus influenzae b a 1.5-kb kanamycin resistance gene. The resultant strain (RKAW5) was tested by Southern analysis, hemagglutination, and electron-micrographic examination to confirm gene inactivation. In comparison with the parent, RKAW5 exhibited a significant decrease in adherence to human buccal epithelial cells and in nasal colonization of yearling rhesus monkeys.

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