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Review
. 2006 Sep;7(9):696-701.
doi: 10.1038/nrm1980. Epub 2006 Jul 5.

Metabolic cycles as an underlying basis of biological oscillations

Benjamin P Tu  1 , Steven L McKnight
Affiliations
Review

Metabolic cycles as an underlying basis of biological oscillations

Benjamin P Tu et al. Nat Rev Mol Cell Biol. 2006 Sep.

Abstract

The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

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