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Comparative Study
. 2006 Jul;5(7):1785-91.
doi: 10.1021/pr0600778.

SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells

Cris Kamperschroer  1 , Susan L Swain, Thomas Grussenmeyer, Ivan Lefkovits
Affiliations
Comparative Study

SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells

Cris Kamperschroer et al. J Proteome Res. 2006 Jul.

Abstract

Deficiency in a protein called signaling lymphocytic activation molecule-associated protein (SAP) causes X-linked lymphoproliferative disease (XLP) and helper T cell-dependent antibody defects. To identify proteins regulated by SAP, we performed proteomic analyses of SAP deficient vs wild type T cells. Our results reveal protein species whose abundances are profoundly altered by SAP. Our work therefore identifies candidate cellular mediators of SAP-dependent T cell help.

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