Review
doi: 10.1016/j.cardiores.2006.06.004.
Epub 2006 Jun 6.
Vascular smooth muscle cell senescence in atherosclerosis
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- PMID: 16824498
- DOI: 10.1016/j.cardiores.2006.06.004
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Review
Vascular smooth muscle cell senescence in atherosclerosis
Cardiovasc Res.
.
Abstract
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.
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