doi: 10.1016/j.bmcl.2006.06.059.
Epub 2006 Jul 7.
Synthesis and cardiac effects of 3,4-dihydropyrimidin-2(1H)-one-5 carboxylates
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- PMID: 16824758
- DOI: 10.1016/j.bmcl.2006.06.059
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Synthesis and cardiac effects of 3,4-dihydropyrimidin-2(1H)-one-5 carboxylates
Bioorg Med Chem Lett.
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Abstract
A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.
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