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. 2006 Oct;87(1-3):28-31.
doi: 10.1016/j.schres.2006.06.008. Epub 2006 Jul 7.

COMT genotype and manic symptoms in schizophrenia

Pamela DeRosse  1 , Birgit Funke, Katherine E Burdick, Todd Lencz, Terry E Goldberg, John M Kane, Raju Kucherlapati, Anil K Malhotra
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COMT genotype and manic symptoms in schizophrenia

Pamela DeRosse et al. Schizophr Res. 2006 Oct.

Abstract

Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.

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