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Clinical Trial
. 2006 Aug;94(2):149-55.
doi: 10.1016/j.ijgo.2006.05.027. Epub 2006 Jul 7.

Misoprostol and active management of the third stage of labor

N Prata  1 , S Hamza, R Gypson, K Nada, F Vahidnia, M Potts
Affiliations
Clinical Trial

Misoprostol and active management of the third stage of labor

N Prata et al. Int J Gynaecol Obstet. 2006 Aug.

Abstract

Objective: To compare current practices for the active management of the third stage of labor (AMTSL) with the use of 600 mug of oral misoprostol.

Methods: An operations research study was designed to compare blood loss with current AMTSL practices and misoprostol use.

Results: Women in the misoprostol group were less likely to bleed 500 ml or more (adjusted odds ratio, 0.30; 95% confidence interval, 0.16-0.56) compared with those in the current practices group. In the current practices group 73% women required interventions because of postpartum hemorrhage, compared with 11% in the misoprostol group.

Conclusion: In situations where oxytocin and or ergometrine are not consistently and appropriately used during third stage of labor, misoprostol should be considered for inclusion in the AMTSL protocol.

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