The regulation of substrate utilization

Abstract

The factors which regulate the utilization of blood-borne substrates by mammalian tissues are discussed. These include the availability of the substrates, the blood flow to tissues, the permeability of cells to the substrate, the activities of initiating enzymes and the regulation of the metabolic pathway. These various factors are illustrated by specific examples. In addition, the methodology involved in measurement of substrate utilization by tissues is briefly outlined.