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Case Reports
. 2006 Jul-Aug;64(4):347-52.

[Spontaneously acquired haemophilia: report of a patient with prostatic adenoma]

[Article in French]
F Barrier  1 , A de La Guerenne, E Semjen, L Wierre, S Horrent, B Decaudin, J P Resibois, M P Weillaert, R Azar, P Odou
Affiliations
  • PMID: 16829479
Free article
Case Reports

[Spontaneously acquired haemophilia: report of a patient with prostatic adenoma]

[Article in French]
F Barrier et al. Ann Biol Clin (Paris). 2006 Jul-Aug.
Free article

Abstract

We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.

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