Review
doi: 10.1038/nrm1962.
EGF-ERBB signalling: towards the systems level
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- PMID: 16829981
- DOI: 10.1038/nrm1962
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Review
EGF-ERBB signalling: towards the systems level
Nat Rev Mol Cell Biol.
2006 Jul.
Abstract
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
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