Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul;7(7):517-28.
doi: 10.1038/nrm1963.

Poly(ADP-ribose): novel functions for an old molecule

Valérie Schreiber  1 , Françoise Dantzer, Jean-Christophe Ame, Gilbert de Murcia
Affiliations
Review

Poly(ADP-ribose): novel functions for an old molecule

Valérie Schreiber et al. Nat Rev Mol Cell Biol. 2006 Jul.

Abstract

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources