Chronic liver disease in a patient with sickle cell anemia

Abstract

Various disorders of the hepatobiliary system can occur due to sickling in patients with sickle cell anemia. Pathology and frequency of these disorders are not clearly known. Liver biopsies of these patients show erythrocytosis, erythrophagocytosis, sinusoidal dilatation and hyperplasia in Kupffer cells. We present a 21-year-old male patient diagnosed with sickle cell anemia who developed chronic liver disease, together with a review of the literature.