Error thresholds in genetic algorithms
- PMID: 16831105
- DOI: 10.1162/evco.2006.14.2.157
Error thresholds in genetic algorithms
Abstract
The error threshold of replication is an important notion in the quasispecies evolution model; it is a critical mutation rate (error rate) beyond which structures obtained by an evolutionary process are destroyed more frequently than selection can reproduce them. With mutation rates above this critical value, an error catastrophe occurs and the genomic information is irretrievably lost. Therefore, studying the factors that alter this magnitude has important implications in the study of evolution. Here we use a genetic algorithm, instead of the quasispecies model, as the underlying model of evolution, and explore whether the phenomenon of error thresholds is found on finite populations of bit strings evolving on complex landscapes. Our empirical results verify the occurrence of error thresholds in genetic algorithms. In this way, this notion is brought from molecular evolution to evolutionary computation. We also study the effect of modifying the most prominent evolutionary parameters on the magnitude of this critical value, and found that error thresholds depend mainly on the selection pressure and genotype length.
Similar articles
-
Effect of lethality on the extinction and on the error threshold of quasispecies.J Theor Biol. 2010 Feb 21;262(4):733-41. doi: 10.1016/j.jtbi.2009.10.011. Epub 2009 Oct 13. J Theor Biol. 2010. PMID: 19833133
-
Agent-based model of genotype editing.Evol Comput. 2007 Fall;15(3):253-89. doi: 10.1162/evco.2007.15.3.253. Evol Comput. 2007. PMID: 17705779
-
The hierarchical fair competition (HFC) framework for sustainable evolutionary algorithms.Evol Comput. 2005 Summer;13(2):241-77. doi: 10.1162/1063656054088530. Evol Comput. 2005. PMID: 15969902
-
Measuring spontaneous deleterious mutation process.Genetica. 1998;102-103(1-6):183-97. Genetica. 1998. PMID: 9720279 Review.
-
Evolutionary algorithms for the satisfiability problem.Evol Comput. 2002 Spring;10(1):35-50. doi: 10.1162/106365602317301763. Evol Comput. 2002. PMID: 11911782 Review.
Cited by
-
Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover.Sci Rep. 2017 Nov 14;7(1):15519. doi: 10.1038/s41598-017-14628-x. Sci Rep. 2017. PMID: 29138394 Free PMC article.
-
Average Fitness Differences on NK Landscapes.Theory Biosci. 2020 Feb;139(1):1-7. doi: 10.1007/s12064-019-00296-0. Epub 2019 Jun 18. Theory Biosci. 2020. PMID: 31214941
-
Viral quasispecies evolution.Microbiol Mol Biol Rev. 2012 Jun;76(2):159-216. doi: 10.1128/MMBR.05023-11. Microbiol Mol Biol Rev. 2012. PMID: 22688811 Free PMC article. Review.
-
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.PLoS Pathog. 2010 Aug 26;6(8):e1001072. doi: 10.1371/journal.ppat.1001072. PLoS Pathog. 2010. PMID: 20865120 Free PMC article.
-
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.PLoS One. 2013 Aug 16;8(8):e71039. doi: 10.1371/journal.pone.0071039. eCollection 2013. PLoS One. 2013. PMID: 23976977 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources