Comparative Study
RGD-containing peptides of VP1 of foot-and-mouth disease virus (FMDV) prevent virus infection in vitro
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- PMID: 1683122
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Comparative Study
RGD-containing peptides of VP1 of foot-and-mouth disease virus (FMDV) prevent virus infection in vitro
Acta Virol.
1991 Jan.
Abstract
RGD-containing peptides from the immunodominant region of VP1 between amino acids 135-160 from foot-and-mouth disease virus (FMDV) type O1 Kaufbeuren (O1K) prevented virus adsorption to piglet kidney (PK) cells. The highly conserved amino acid RGD sequence (Arg.-Gly.-Asp.) was a prerequisite of this effect. To prevent infection with 100-200 TCID50 in 10(6) PK cells, 20-250 micrograms of each peptide should have been added.
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