Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle
- PMID: 168317
- PMCID: PMC491903
- DOI: 10.1136/jnnp.38.3.241
Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle
Abstract
Histopathological findings of biopsied peripheral nerve and muscle were studied in a case with myxoedematous polyneuropathy. The most striking findings in the sural nerve were segmental demyelination and onion bulb formation with scanty mucinous deposits in addition to marked loss of large myelinated nerve fibres. The peroneus brevis muscle revealed the association of neuropathic and myopathic changes. It is suggested that myxoedematous polyneuropathy might be intrinsic neuropathy due to metabolic disorder of Schwann cells related to hypothyroidism, resulting in segmental demyelination, not merely compressive neuropathy due to mucinous deposits in the peripheral nerves.
Similar articles
-
Giant axonal neuropathy: a childhood disorder of microfilaments.Ann Neurol. 1977 May;1(5):438-51. doi: 10.1002/ana.410010507. Ann Neurol. 1977. PMID: 214018
-
Dynamic aspects of peripheral nerve changes in progressive neural muscular atrophy: light- and electronmicroscopic studies of serial nerve biopsies.J Neurol. 1976 Jan 14;211(2):111-24. doi: 10.1007/BF00313355. J Neurol. 1976. PMID: 55467
-
Symmetric sarcoid polyneuropathy: analysis of a sural nerve biopsy.Neurology. 1981 Oct;31(10):1217-23. doi: 10.1212/wnl.31.10.1217. Neurology. 1981. PMID: 6287346
-
[Subacute myeloneuropathy after abuse of nitrous oxide: an electron microscopic study on the peripheral nerve].Rinsho Shinkeigaku. 1989 Sep;29(9):1129-35. Rinsho Shinkeigaku. 1989. PMID: 2557181 Review. Japanese.
-
Sarcoidosis of the peripheral nervous system.Neurol Res. 1993 Dec;15(6):389-90. doi: 10.1080/01616412.1993.11740169. Neurol Res. 1993. PMID: 7907406 Review.
Cited by
-
Relationship between subclinical hypothyroidism and distal-symmetric diabetic polyneuropathy in type 2 diabetes mellitus referred to Kosar Hospital in Semnan and related indicators in 2019-2020.J Family Med Prim Care. 2022 Apr;11(4):1361-1368. doi: 10.4103/jfmpc.jfmpc_1262_21. Epub 2022 Mar 18. J Family Med Prim Care. 2022. PMID: 35516707 Free PMC article.
-
Hypothyroid neuropathy and myopathy: clinical and electrodiagnostic longitudinal findings.J Neurol. 1990 Jul;237(4):271-4. doi: 10.1007/BF00314634. J Neurol. 1990. PMID: 2391552
-
Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature.Rev Endocr Metab Disord. 2016 Dec;17(4):499-519. doi: 10.1007/s11154-016-9357-0. Rev Endocr Metab Disord. 2016. PMID: 27154040 Review.
-
Peripheral neuropathy in hypothyroidism--an association with spurious polycythaemia (Gaisbock's syndrome).J R Soc Med. 1983 Mar;76(3):187-9. doi: 10.1177/014107688307600306. J R Soc Med. 1983. PMID: 6300398 Free PMC article.
-
Myeloneuropathy associated with hypothyroidism.Br Med J. 1977 Apr 16;1(6067):1005-6. doi: 10.1136/bmj.1.6067.1005-a. Br Med J. 1977. PMID: 192406 Free PMC article. No abstract available.
References
MeSH terms
LinkOut - more resources
Full Text Sources