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Comparative Study
. 2006 Jul 11;67(1):64-8.
doi: 10.1212/01.wnl.0000223438.90113.4e.

Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease

P I Lin  1 , E R Martin, P G Bronson, C Browning-Large, G W Small, D E Schmechel, K A Welsh-Bohmer, J L Haines, J R Gilbert, M A Pericak-Vance
Affiliations
Comparative Study

Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease

P I Lin et al. Neurology. .

Abstract

Background: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD.

Methods: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs.

Results: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003).

Conclusions: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.

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